Helicobacter pylori is a common human pathogen that infects about half of the world's population. Helicobacter pylori infection can lead to a series of gastrointestinal diseases of varying degrees, such as chronic gastritis, indigestion, and peptic ulcers. Meanwhile, Helicobacter pylori is also a clear human grade I carcinogen and an important cause of gastric cancer. Eradicating Helicobacter pylori infection not only improves gastrointestinal diseases associated with it, but also effectively reduces the risk of developing gastric cancer.

Helicobacter pylori can be said to be a bacterium with a very "Chinese color". According to reports, approximately 700 million Chinese people have been infected with Helicobacter pylori. It is a spiral shaped, microaerophilic bacterium that requires very strict growth conditions. Bad breath, stomach ulcers, and even stomach cancer may all be caused by Helicobacter pylori. This type of bacteria can be spread through saliva, utensils, and daily food picking, and it is common for the whole family to be affected.

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The problem of Helicobacter pylori drug resistance is becoming increasingly serious

In recent years, with the widespread development of treatment against Helicobacter pylori, bismuth quadruple therapy is currently considered the main empirical approach for combating Helicobacter pylori. Although the infection rate has decreased, the accompanying issues of antibiotic resistance, low compliance, and easy recurrence of infection continue to emerge, becoming another major challenge for Helicobacter pylori eradication treatment. Therefore, there is an urgent need to research non antibiotic alternatives.

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Nowadays, both the medical and scientific industries have been seeking new methods to combat Helicobacter pylori. At the same time, with the rise of gut microbiome research, the approach of "treating bacteria with bacteria" has gradually attracted widespread attention in academia.

Inactivated extracellular vesicles have been found to have targeted anti dark advantages

Since the discovery of bacteria, we humans have been fighting against them, from the early penicillin to the growing antibiotic family today. Probiotics are beneficial microorganisms for human health. Currently, a large amount of basic and clinical research has focused on the different health benefits of probiotics, including their use as adjunctive therapy for eradicating Helicobacter pylori.

Postbiotics is a collective term for the metabolites of probiotics that have been processed, including bacterial cells and metabolites. It has been confirmed through research that the selected epigenetic elements enhance immune function better than the original live bacteria. Even after high-temperature treatment or gastrointestinal digestion, they still maintain high physiological activity. Moreover, epigenetic elements have the advantages of high safety, direct and rapid functional control, no population restrictions, and longer and more stable shelf life. Previous studies have shown that supplementing with prebiotics can be beneficial for the gut, as it can reduce inflammation and bacteria, enhance the intestinal barrier function, and allow the originally "beneficial bacteria" in the gut to grow vigorously, helping the gut to cultivate its own beneficial bacteria. However, the evidence for this is still unclear and further experiments are needed.

Yuanda BiotechnologyDr. Peng Chuantao, the founder of Yuanda Biotechnology, is a leading enterprise in the field of metagenomics. He has been deeply involved in this field for decades and has achieved remarkable results. Recently, his project "Targeted Functional Metagenomics Research and Industrialization" won the 5th China National Congress The gold medal of Shandong Postdoctoral Innovation and Entrepreneurship Competition is widely praised as a leading talent in the field of post doctoral education. Dr. Peng Chuantao has made significant achievements in the field of epigenetics research. In the fight against Helicobacter pylori, he led his team to confirm through continuous research and multiple rounds of experiments that the epigenetics achievement Postbiocare ® Targeted inhibition of Helicobacter pylori is more effective, and using it as a substitute for antibiotics may also help address the global burden of antibiotic resistance.

Targeted antimicrobial therapy as an alternative to antibiotics——Postbiocare ®

Postbiocare ® It can have a targeted inhibitory effect on Helicobacter pylori by recognizing its surface protein structure and binding to it to form a copolymer, which is then excreted from the body through the gastrointestinal tract, thereby reducing the number of Helicobacter pylori in the stomach.

Dr. Peng said that in layman's terms, this Postbiocare ® Being able to search for Helicobacter pylori throughout the gastric mucosa, once found, it will tightly bind with the bacteria, pulling them out of the mucosa and ultimately excreting them together.

We will first conduct a set of experiments provided by Dr. Peng to better understand its mechanism of action.

Adsorption experiment

Through quartz crystal microbalance (QCM), it has been demonstrated that, Postbiocare ® It can quickly identify and bind to Helicobacter pylori, then specifically bind to Helicobacter pylori, form aggregates, and be excreted through the digestive tract.

Let's take a look again at Postbiocare, a type of young adult ® How effective is the suppression of darkness?

Antibacterial test

Through the antibacterial zone experiment, it has been proven that, Postbiocare ® It can significantly inhibit the growth of Helicobacter pylori and is 2-3 times more effective than other products on the market. After further recruiting volunteers for experimental analysis (recruiting 50 patients with superficial gastritis, gastric ulcer, Helicobacter pylori, etc.), the results were similar, which increased the weight of the research findings.

Based on the above experimental results, Postbiocare ® The principle of highly targeted anti ulcer therapy is very clear, which can effectively alleviate gastritis and gastric ulcers caused by Helicobacter pylori, improve symptoms such as superficial gastritis and gastroesophageal reflux.  

It is precisely because the secondary metabolites are all inactivated that there is no need to worry about the safety of stomach acid and bacteria.

The path of resisting "darkness" is long and obstructed. Postbiocare ® As a breakthrough discovery in the field of anti youjie, mild supplements to existing therapies have no side effects/dependence, and are expected to provide a reliable alternative to daily antibiotics for targeted treatment of anti youjie stomach, giving it confidence to adopt strategies that avoid long-term use of antibiotics.