Recently, the internationally renowned academic journal "Cell Metabolism" published a paper online titled "Unlocking the Power of Postbiotics: A Revolutionary Approach to Nutrition for Humans and Animals", exploring new pathways and mechanisms of the impact of Postbiotics on human and animal nutrition and health.

This study comprehensively elucidates the possible sources, future development trends, and applications of epigenetics, and takes the lead in revealing the effects of epigenetics on the healthy development of the body from the aspects of host antioxidant activity regulation, immune regulation, gut microbiota modification, and enhanced epithelial barrier function. It lays a solid theoretical foundation for the application of epigenetics in humans and animals, and provides new research directions for further exploring new epigenetics preparations.

The mechanism of antioxidant properties of epigenetic elements

The immune regulatory function of host by the binding of epigenetic elements and yeast cell wall components to epithelial pattern recognition receptors

The study suggests that the potential mechanisms of action of epigenetic preparations in the host include:

(1) Improve antioxidant performance.Epigenetic preparations can regulate host antioxidant mechanisms by chelating with metal ions, generating antioxidant substances, upregulating host antioxidant activity or related gene expression, regulating signaling pathways, reducing reactive oxygen species (ROS) enzyme activity, and regulating gastrointestinal microbiota.

(2) Immune response regulation.Postbiotics can regulate host immune responses by interacting with epithelial cells, dendritic cells, monocytes/macrophages, and lymphocytes.

(3) Microbial community regulation.Postbiotics can regulate host microbiota through three different pathways, including inhibiting pathogen growth through antibacterial substances such as bacteriocins; By introducing organic acids to regulate the pH level of the internal environment, favorable conditions for the growth of probiotics can be established while preventing the proliferation of pathogens; By using certain structural components such as pili and lectins, specific sites adhere or bind in the host's internal environment, thereby preventing the adhesion of pathogens.

(4) Enhance intestinal epithelial barrier function.The fatty acids (LTA), surface layer proteins, short chain fatty acids (SCFAs), and certain secreted proteins present in epigenetic preparations can play a protective role in maintaining intestinal barrier function.

The regulatory function of human and animal gastrointestinal microbiota mediated by postnatal elements

This research further confirms that the emerging field of microbial metabolites, such as epigenetics, is revolutionizing nutrition and health sciences. In recent years, with its significant advantages in stability and safety, Postbiotics has not only provided innovative solutions for the food, health products, and pharmaceutical industries, but also become an important driving force for building a healthy, green, and sustainable society due to its unique green and sustainable attributes.

In recent years, with the acceleration of people's pace of life, gastric damage caused by external factors such as excessive alcohol consumption and stimulating food has gradually increased, which can further lead to diseases such as ulcers, inflammatory bowel disease, and gastrointestinal cancer. Based on this, Yuanda Biology has been breaking through the major problem of gastric health in China for many years through evidence-based research and independent innovation. It has independently developed the first targeted anti gastric and highly effective post gastric star product - Postbiocare ®。

It can effectively inhibit excessive secretion of gastric acid, reduce the adhesion of Helicobacter pylori to gastric mucosal cells, relieve bloating symptoms, slow down inflammation, help repair gastric mucosa, and significantly improve symptoms such as superficial gastritis, esophageal reflux, heartburn, etc.

Efficient antibacterial experiment: Through the antibacterial zone experiment, it has been proven that, Postbiocare ® It can significantly inhibit the growth of Helicobacter pylori.

Adsorption experiment: It was demonstrated through quartz crystal microbalance (QCM) that, Postbiocare ® Can quickly identify and bind to Helicobacter pylori.

Yuanda Biotechnology has always been committed to the development of functional epigenetic raw materials, which is in line with the current national "Big Health" strategy and the "Healthy China 2030 Plan".

As a pioneer in the field of endogenous microorganisms in China, Yuanda Biotechnology has a profound research and development background in probiotics and endogenous microorganisms. It has jointly established the "Innovative Platform for Basic Research and Development of Probiotics and Endogenous Pathogens" with the Special Food Research Institute of Qingdao Agricultural University.

Among them, "Key Technologies and Applications for the Preparation of High Concentration Compound Probiotics and Their Metabolites (Epibiotics)" was rated as "International Leading" level, which is the first scientific and technological achievement in the field of Epibiotics in China to reach world-class high standards. At the same time, Yuanda Biotechnology also served as the main drafting unit to formulate the first group standard for Epibiotics in China, and organized the first China Epibiotics Science and Technology Conference in 2022, leading the continuous improvement of the "technological core" of high-quality development of China's Epibiotics industry.