Dr. Li Zhaojie was invited to attend the 20th Symposium on Probiotics and Health and give a special report

2026-04-30 08:54:58 Page views: 663 Author: 元达生物

2026-04-30 08:54:58 Author: 元达生物

The 20th Symposium on Probiotics and Health, hosted by the Chinese Society for Food Science and Technology (CIFST), was held in Beijing from May 19th to 21st. The conference, with the theme of "Deepening the Achievements of Science and Technology, Integrating Development, and Embarking on a New Journey," freely expressed opinions on cutting-edge technological directions and hotspots, industrial development trends and new demands, technological bottlenecks and key breakthrough directions in various fields, and provided suggestions and recommendations for the high-quality development of the industry. Yuanda Biotechnology was invited to attend the conference, and Dr. Li Zhaojie, the General Manager of the company, gave a special report on the anti-inflammatory effects and mechanisms of PostbioP-6.

Inflammation is the natural defense mechanism of the human body against infection and damage, but when the inflammatory response is out of control or persists for a long time, it can evolve into chronic inflammation, becoming the core cause of major health problems such as cancer, cardiovascular disease, and autoimmune diseases. About 50% of global deaths are related to chronic inflammation. In recent years, with the deepening of research on gut microbiota,postbioticsbecause ofUnique anti-inflammatory mechanism and safetyBecoming a cutting-edge solution for alleviating chronic inflammation.

Cell experiment resultsdisplayPostbioP-6 can significantly reduce the release of inflammatory factors (TNF - α, IL-6, IL-1 β) and inflammatory mediators (NO, PGE2) in the LPS induced RAW264.7 inflammatory cell model, while significantly reducing the level of intracellular ROS,proofPostbioP-6canSignificantly inhibit the inflammatory response of inflammatory cells.

The results of in vivo experiments on zebrafish showed that the epigenetic elementsPostbioP-6 can significantly reduce the aggregation of neutrophils in the inflammatory site of zebrafish, significantly decrease the expression of inflammation related factors TNF - α, IL-6, IL-8, IL-1 β, and iNOS in zebrafish, and significantly reduce the level of ROS in zebrafish,proofPostbioP-6 can significantly inhibit the inflammatory response in the body.

In terms of anti-inflammatory mechanisms, the results showed that,postbioticsPostbioP-6By inhibiting the ubiquitination degradation of I κ B and the phosphorylation of p65 protein to prevent its nuclear translocation, the activation of the NF - κ B pathway is inhibited; At the same time, by inhibiting the phosphorylation of p38 protein and JNK protein, the activation of MAPK pathway is suppressed, and the ERK pathway is activated to prevent cell apoptosis caused by the activation of p38 and JNK pathwaysPlay an anti-inflammatory role.

Induction of colitis model rats with dextran sulfate sodium (DSS) and administrationPostbioP-6Afterwards, symptoms of enteritissignificantly improvedAnd the improvement effect is positively correlated with the dose of endogenous factors. The weight of the rats returned to normal and the colon tissue was repaired.

PostbioP-6haveAnti inflammatory, antioxidant, anti hemolytic, relieve constipationThe efficacy, andStable properties, acid, alkali, and high temperature resistanceIt can be widely used in functional foods, such as post production beverages, post production yogurt, post production coffee, post production pastries, and various other products.