It is reported that the famous Japanese musician Ryuichi Sakamoto passed away on March 28th at the age of 71 due to colorectal cancer. The football king Pele, who passed away at the age of 82, was also killed by rectal cancer. However, this disease is not exclusive to the elderly, as the lead actor of "Black Panther," Chavik Boseman, also passed away from colorectal cancer at the age of 43.

Colorectal cancer (CRC) is the third most common malignant tumor in the world, and also the second most common malignant tumor in incidence rate in China. According to a CA research report, in 2023, 153000 people in the United States will be diagnosed with colorectal cancer (CRC). In these cases, about 13% of patients are younger than 50 years old - this means that although the incidence rate and mortality of colorectal cancer (CRC) continue to decline, its incidence rate is getting younger [1].

Faced with the urgent situation of colorectal cancer, its relationship with gut microbiota has also received attention. There are 400 to 500 species of bacteria colonized in the human gut, totaling 1013 to 1014 bacteria, which is about 10 times the total number of human cells. Under normal circumstances, the gut microbiota is in a symbiotic state with the human body, and maintaining a relatively stable state is essential for protecting the body's health and preventing certain diseases. Therefore, once gastrointestinal diseases or lesions occur and infections occur, they are mostly caused by dysbiosis/dysbiosis of the gut microbiota (dysbiosis and translocation), which in turn increases the risk of developing colorectal cancer.

The intestine is the largest immune organ in the human body, with 70% of immune cells and immunoglobulins concentrated in the intestine. Gut health is one of the important indicators of human health. Probiotics and prebiotics, which are closely related to intestinal health, can better regulate intestinal health, enhance intestinal immunity, and improve the body's immune function. Postnatal cells are also hailed by scientists as the 'vaccine of the future era'!

The Academic Concept of Postbiotics

The concept of postbiotics was first proposed by Spanish scientist Katerina Tsilingiri in 2013. In 2019, under the leadership of the International Association of Probiotics and Prebiotics Sciences (ISAPP), an expert group reviewed the definition and scope of prebiotics. Until 2021, ISAPP published a "consensus statement" in the journal Nature Reviews Gastroenterology and Hepatology, giving birth to the "official" concept of non living microorganisms and/or their components that are beneficial to host health.

This definition emphasizes that regardless of whether bacterial metabolites are present or not, effective epigenetic elements must contain inactivated microbial cells or cellular components, and must be proven to be beneficial to health.

Postbiotics have probiotic functions and advantages for the intestine

The epigenetic element is an excellent health effector. From in vitro experiments, animal experiments to clinical experiments, studies involving epigenetic elements have proved that epigenetic elements have many beneficial health effects, such as preventing pathogen infection, regulating intestinal flora, strengthening intestinal epithelial barrier, improving intestinal immunity, alleviating diarrhea and constipation, preventing and treating multiple metabolic diseases such as hypertension and diabetes, improving body immunity, anti allergy, regulating nervous system, and relieving nerves.

Compared with previous probiotics, prebiotics, and synbiotics products, prebiotics have the advantages of a fixed chemical structure, safe and non-toxic microbial inactivation, longer shelf life, and beneficial maintenance of host homeostasis.

PostbioP ®- Post-90s Generation: A New Solution for Health Regulation

Yuanda Biotech launches functional PostbioP ®- 6， PostbioP ®- 6 is a new generation of probiotic+prebiotic gut microbiota regulation and probiotic solution, using probiotic strains derived from naturally fermented milk and healthy breast milk. With unique metabolic regulation, metabolic and growth interaction, functional ingredient embedding and other technologies (patented technology), Yuanda Biotech has developed a new generation of functional prebiotic products that are more resistant to industrial heat processing and human stomach acid than normal probiotics. Through multiple clinical medical evidence-based mining of new efficacy of strains, it has been proven that P6 can significantly improve the symptoms of inflammatory bowel disease (IBD) by reducing pro-inflammatory cytokines, increasing anti-inflammatory cytokines, enhancing vitamin E synthesis and fatty acid synthesis metabolic pathways, regulating the homeostasis of the entire digestive tract microbiota, enhancing the intestinal mucosal barrier, improving intestinal immunity, and further enhancing the overall immune capacity of the body.

① Innovative, rigorous, and forward thinking research team

Its advantageous strains are entirely derived from provincial authoritative laboratories in China. The laboratory is led by the founder and chief scientist Peng Chuantao, and is a research team that collaborates with six major provincial and ministerial universities, including Qingdao Special Food Research Institute, Probiotics and Postbiotics Basic Research and Development Application Innovation Platform, Key Laboratory of Special Food Processing of the Ministry of Agriculture and Rural Affairs (jointly built by the Ministry and the Province), Shandong Special Food Technology Innovation Center, Shandong Special Food Collaborative Innovation Center, and Provincial Special Food Science and Technology Characteristic Laboratory. The research platform is dedicated to targeted functional Postbiotics development and application research, creating a benchmark for Chinese Postbiotics research and "intelligent" manufacturing. The strains independently developed based on clinical trials of the domestic population are more universal for the Chinese people.

② Yuanda Biotech PostbioP ®- 6. Wide application prospects

With the continuous deepening of epigenetic research, the increasing awareness of health care, and the growing demand for healthy food, PostbioP ®- With its diverse potential benefits and good stability, it has gradually gained popularity among people. Postbiotics not only brings better and safer probiotic functional solutions, but also promotes the leapfrog development of a series of basic and applied sciences such as microbiology, nutrition, food processing technology, flavor texture adjustment technology, preservation technology, etc. This will greatly enrich the dimensions of food innovation and be widely applied in fields such as general food, nutritional supplements, special medical foods, and infant and toddler foods.

In terms of ordinary food, such as common dairy products, seasonings, pre made dishes, snacks, beverages, etc., traditional food is given "functionalization" to promote its transformation and upgrading, enhance its high-tech added value and market competitiveness; It can be used to manufacture dietary supplements in the field of nutritional supplements; In the field of special medical food, it is used to treat gastrointestinal diseases; It can also be applied in infant and toddler food, for example, by adding inactivated microorganisms to many infant formula, it can achieve dual supplementation of traditional nutrients such as protein and postnatal elements, enhancing immunity.

Yuanda Biotechnology - a leader in the functional post cellular industry

As a pioneer in the research and manufacturing of next-generation raw materials in China, Yuanda Biotechnology has always been driven by research and innovation, and has built China's first next-generation screening strain resource library with independent intellectual property rights. Currently, it has collected more than 3000 strains of strains, which is also the industry's largest high-density production strain.

Through the dual drive of research and development and production, Yuanda Biotechnology continuously improves its technology and product layout. In addition to PostbioP, a functional food ingredient derived from epigenetic elements ®- In addition to the 6 Postnatal Elements, Yuanda Biotechnology also has multiple Postnatal Elements products evaluated in clinical trials: patented skincare ingredient - Bilantera ®、 PostbioMT, a raw material for oral antibacterial treatment ®、 Protecting Pet Health Raw Materials - PostbioA ®- Grade 6 is highly favored by the market and praised by the industry, and has entered the stage of large-scale production, helping to promote the high-quality development of the industry.

At any time, health always comes first. In the future, Yuanda Biotechnology will continue to adhere to scientific research and innovation, guided by customer needs, to create functional products that are more suitable for Chinese people. We will work together with relevant scientific research platforms and enterprises to provide more high-quality probiotic products with scientific evidence, health benefits, and improved consumer experience, better helping the big health industry achieve high-quality development.

[1]. IARC 2021.https://www.iarc.fr/faq/latest-global-cancer-data-2020-qa/.